Sex-based differences in psychiatric symptoms and opioid abstinence during buprenorphine/naloxone treatment in adolescents with opioid use disorders

This paper examined sex-based differences in psychiatric symptoms and relationships among sex, psychiatric symptoms, and opioid use outcomes in youth with OUD receiving buprenorphine/naloxone (Bup/Nal) and psychosocial treatment. We found that clinically significant sex-based differences in psychiatric symptoms are present at baseline among youth with opioid use disorder receiving Bup/Nal-assisted treatment and mostly resolve during treatment.

Recommended citation: Hammond, C. J., Park, G., Kady, A., Rathod, K., Rahman, N., Vidal, C., Wenzel, K., & Fishman, M. (2022). Sex-based differences in psychiatric symptoms and opioid abstinence during buprenorphine/naloxone treatment in adolescents with opioid use disorders. Journal of substance abuse treatment, 133, 108495. https://doi.org/10.1016/j.jsat.2021.108495