Alcohol: Clinical and Experimental Research,
Recommended citation: Grodin, E., Kady, A., & Ray, L. (2024). The future of reward and relief drinking profiles: Considerations for social motives, stability of profiles, and tailored interventions. Alcohol: Clinical and Experimental Research. doi: 10.1111/acer.15269
Psychopharmacology,
To test a novel human laboratory model in which individuals with intrinsic motivation to change their drinking engage in a “practice quit” attempt consisting of 6 days of complete abstinence from alcohol.
Recommended citation: Ray, L., Baskerville, W., Nieto, S., Grodin, E., Enders, C., Kady, A., Meredith, L., Gillis, A., Leventhal, A., Ho, D., & Miotto, K. (2024). A Practice Quit Model to Test Early Efficacy of Medications for Alcohol Use Disorder in a Randomized Clinical Trial. Psychopharmacology. doi: 10.1007/s00213-023-06504-6
Development and Psychopathology,
This paper investigated age differences in marriage effects on problem-drinking reduction. Results showed marriage effects are the strongest in early young adulthood and decrease thereafter with age, reaching very small (and nonsignificant) magnitudes by the 30s. Results may reflect that role transitions like marriage have more impact on problem drinking in earlier versus later adulthood, thereby highlighting the importance of life span developmental research for understanding problem-drinking desistance.
Recommended citation: Lee, M. R., Yeung, E. W., Littlefield, A. K., Stephenson, A., Kady, A., Kwan, T., Chassin, L., & Sher, K. J. (2022). A life span developmental investigation of marriage and problem-drinking reduction. Development and psychopathology, 1–11. Advance online publication. https://doi.org/10.1017/S0954579422000827
Neuropsychopharmacology,
This paper provides a nuanced understanding of the impact of early life stress (ELS) in AUD, suggesting that high-ELS (4+ ACEs) is associated with a greater negative emotionality and elevated CRP. ELS was not associated with incentive salience, thereby indicating a dissociation of the effects of ELS on AUD phenomenology. This study found support for the overarching hypothesis that individuals with and without a history of ELS and the same primary DSM-5 diagnosis are clinically and biologically distinct in the context of AUD [11, 12], and suggests that tailored treatments for this group, including neuroimmune modulators, are in need of investigation.
Recommended citation: Kirsch, D., Grodin, E., Nieto, S., Kady, A., & Ray, L. (2024). Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder. Psychopharmacology. doi: 10.1038/s41386-024-01877-4
Journal of Addiction Medicine,
This paper used data from the NIDA-CTN-0010 trial to evaluate the mediating effects of psychosocial treatment-related variables (therapy dose and therapeutic alliance) on end-of-treatment opioid abstinence in a sample of youth with Opioid Use Disorder. We found that participants in the Bup-Nal group attended more therapy sessions (16 vs 6 sessions), had increased therapeutic alliance at week-4, and had less opioid use by week-12 compared to those in the Detox group. In both treatment arms, youth who attended more therapy sessions were less likely to have a week-12 opioid positive urine. In a multiple mediator model, therapy dose mediated the association between treatment arm and opioid abstinence.
Recommended citation: Kady, A.,* Hammond, C. J.,* Park, G., Vidal, C., Wenzel, K., & Fishman, M. (2022). Therapy Dose Mediates the Relationship Between Buprenorphine/Naloxone and Opioid Treatment Outcomes in Youth Receiving Medication for Opioid Use Disorder Treatment. Journal of addiction medicine, 16(2), e97–e104. https://doi.org/10.1097/ADM.0000000000000861
*equally contributing first authors
Journal of Substance Abuse Treatment,
This paper examined sex-based differences in psychiatric symptoms and relationships among sex, psychiatric symptoms, and opioid use outcomes in youth with OUD receiving buprenorphine/naloxone (Bup/Nal) and psychosocial treatment. We found that clinically significant sex-based differences in psychiatric symptoms are present at baseline among youth with opioid use disorder receiving Bup/Nal-assisted treatment and mostly resolve during treatment.
Recommended citation: Hammond, C. J., Park, G., Kady, A., Rathod, K., Rahman, N., Vidal, C., Wenzel, K., & Fishman, M. (2022). Sex-based differences in psychiatric symptoms and opioid abstinence during buprenorphine/naloxone treatment in adolescents with opioid use disorders. Journal of substance abuse treatment, 133, 108495. https://doi.org/10.1016/j.jsat.2021.108495