Annabel Kady

Annabel Kady

PhD Student
akady1@ucla.edu

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Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder

Neuropsychopharmacology,

This paper provides a nuanced understanding of the impact of early life stress (ELS) in AUD, suggesting that high-ELS (4+ ACEs) is associated with a greater negative emotionality and elevated CRP. ELS was not associated with incentive salience, thereby indicating a dissociation of the effects of ELS on AUD phenomenology. This study found support for the overarching hypothesis that individuals with and without a history of ELS and the same primary DSM-5 diagnosis are clinically and biologically distinct in the context of AUD [11, 12], and suggests that tailored treatments for this group, including neuroimmune modulators, are in need of investigation.

Recommended citation: 2. Kirsch, D., Grodin, E., Nieto, S., Kady, A., & Ray, L. (2024). Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder. Psychopharmacology. doi: 10.1038/s41386-024-01877-4

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publications

Sex-based differences in psychiatric symptoms and opioid abstinence during buprenorphine/naloxone treatment in adolescents with opioid use disorders

Journal of Substance Abuse Treatment,

This paper examined sex-based differences in psychiatric symptoms and relationships among sex, psychiatric symptoms, and opioid use outcomes in youth with OUD receiving buprenorphine/naloxone (Bup/Nal) and psychosocial treatment. We found that clinically significant sex-based differences in psychiatric symptoms are present at baseline among youth with opioid use disorder receiving Bup/Nal-assisted treatment and mostly resolve during treatment.

Recommended citation: Hammond, C. J., Park, G., Kady, A., Rathod, K., Rahman, N., Vidal, C., Wenzel, K., & Fishman, M. (2022). Sex-based differences in psychiatric symptoms and opioid abstinence during buprenorphine/naloxone treatment in adolescents with opioid use disorders. Journal of substance abuse treatment, 133, 108495. https://doi.org/10.1016/j.jsat.2021.108495

Therapy dose mediates the relationship between buprenorphine/naloxone and opioid treatment outcomes in youth receiving medication for opioid use disorder treatment

Journal of Addiction Medicine,

This paper used data from the NIDA-CTN-0010 trial to evaluate the mediating effects of psychosocial treatment-related variables (therapy dose and therapeutic alliance) on end-of-treatment opioid abstinence in a sample of youth with Opioid Use Disorder. We found that participants in the Bup-Nal group attended more therapy sessions (16 vs 6 sessions), had increased therapeutic alliance at week-4, and had less opioid use by week-12 compared to those in the Detox group. In both treatment arms, youth who attended more therapy sessions were less likely to have a week-12 opioid positive urine. In a multiple mediator model, therapy dose mediated the association between treatment arm and opioid abstinence.

Recommended citation: Kady, A.,* Hammond, C. J.,* Park, G., Vidal, C., Wenzel, K., & Fishman, M. (2022). Therapy Dose Mediates the Relationship Between Buprenorphine/Naloxone and Opioid Treatment Outcomes in Youth Receiving Medication for Opioid Use Disorder Treatment. Journal of addiction medicine, 16(2), e97–e104. https://doi.org/10.1097/ADM.0000000000000861

*equally contributing first authors

Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder

Neuropsychopharmacology,

This paper provides a nuanced understanding of the impact of early life stress (ELS) in AUD, suggesting that high-ELS (4+ ACEs) is associated with a greater negative emotionality and elevated CRP. ELS was not associated with incentive salience, thereby indicating a dissociation of the effects of ELS on AUD phenomenology. This study found support for the overarching hypothesis that individuals with and without a history of ELS and the same primary DSM-5 diagnosis are clinically and biologically distinct in the context of AUD [11, 12], and suggests that tailored treatments for this group, including neuroimmune modulators, are in need of investigation.

Recommended citation: Kirsch, D., Grodin, E., Nieto, S., Kady, A., & Ray, L. (2024). Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder. Psychopharmacology. doi: 10.1038/s41386-024-01877-4

A life span developmental investigation of marriage and problem-drinking reduction

Development and Psychopathology,

This paper investigated age differences in marriage effects on problem-drinking reduction. Results showed marriage effects are the strongest in early young adulthood and decrease thereafter with age, reaching very small (and nonsignificant) magnitudes by the 30s. Results may reflect that role transitions like marriage have more impact on problem drinking in earlier versus later adulthood, thereby highlighting the importance of life span developmental research for understanding problem-drinking desistance.

Recommended citation: Lee, M. R., Yeung, E. W., Littlefield, A. K., Stephenson, A., Kady, A., Kwan, T., Chassin, L., & Sher, K. J. (2022). A life span developmental investigation of marriage and problem-drinking reduction. Development and psychopathology, 1–11. Advance online publication. https://doi.org/10.1017/S0954579422000827

A practice quit model to test early efficacy of medications for alcohol use disorder in a randomized clinical trial

Psychopharmacology,

To test a novel human laboratory model in which individuals with intrinsic motivation to change their drinking engage in a “practice quit” attempt consisting of 6 days of complete abstinence from alcohol.

Recommended citation: Ray, L., Baskerville, W., Nieto, S., Grodin, E., Enders, C., Kady, A., Meredith, L., Gillis, A., Leventhal, A., Ho, D., & Miotto, K. (2024). A Practice Quit Model to Test Early Efficacy of Medications for Alcohol Use Disorder in a Randomized Clinical Trial. Psychopharmacology. doi: 10.1007/s00213-023-06504-6

talks

Sex Differences in Psychiatric Treatment Response During Extended- and Short-term Buprenorphine/Naloxone-assisted Treatment in Opioid-dependent Youth

Published:

Citation: Hammond, C.J., Park, G., Kady, A.; Rathod, K., Rahman, N., Allick, A., Vidal, C.; Wenzel, K., & Fishman, M. (2019, Jan). Sex Differences in Psychiatric Treatment Response During Extended- and Short-term Buprenorphine/Naloxone-assisted Treatment in Opioid-dependent Youth [Conference presentation]. Presented at the 14th Annual Johns Hopkins Bayview Research Symposium, Baltimore, MD.

Depressive symptoms and course are associated with early relapse in opioid-dependent individuals treated with extended-release naltrexone but not buprenorphine-naloxone

Published:

Citation: Hammond, C.J., Park, G., Kady, A., Pollack, A., Wenzel, K., & Fishman, M. (2019, July). Depressive symptoms and course are associated with early relapse in opioid-dependent individuals treated with extended-release naltrexone but not buprenorphine-naloxone [Poster presentation]. Presented at Johns Hopkins Department of Psychiatry and Behavioral Sciences Annual Research Potpourri, Baltimore, MD.

Depressive symptoms and course are associated with early relapse in opioid-dependent individuals treated with extended-release naltrexone but not buprenorphine-naloxone

Published:

Citation: Hammond, C.J., Pollack, A., Miller, L., Park, G., Kady, A., Wenzel, K., & Fishman, M. (2019, September). Depressive symptoms and course are associated with early relapse in opioid-dependent individuals treated with extended-release naltrexone but not buprenorphine-naloxone [Poster presentation]. Presented at the National Network of Depression Centers (NNDC) 11th Annual Conference, Virtual.

Does Therapy Dose and Alliance Affect Treatment Outcomes in Youth Receiving Buprenorphine/Naloxone for Opioid Use Disorders?

Published:

Citation: Hammond, C.J., Kady, A., Park, G., Wenzel, K., & Fishman, M. (2020, October). Depression severity is associated with long-term opioid abstinence in youth with opioid use disorders receiving buprenorphine/naloxone treatment: 12-month outcomes [Poster presentation]. Presented at the 12th Annual National Networks of Depression Centers Conference, Virtual.

Sex-Based Differences in Psychiatric Symptoms and Opioid Abstinence During Buprenorphine/Naloxone-Assisted Treatment in Adolescents with Opioid Use Disorders

Published:

Citation: Hammond, C.J., Kady, A., Park. G., Matson, P., & Fishman, M. (2020, April 25-29). Sex-Based Differences in Psychiatric Symptoms and Opioid Abstinence During Buprenorphine/Naloxone-Assisted Treatment in Adolescents with Opioid Use Disorders [Poster presentation]. Invited to present at American Psychological Association Annual Conference, Philadelphia, PA. (Conference canceled due to COVID-19).

Does Therapy Dose and Alliance Affect Treatment Outcomes in Youth Receiving Buprenorphine/Naloxone for Opioid Use Disorders?

Published:

Citation: Hammond, C.J., Kady, A., Park, G., Wenzel, K., & Fishman, M. (2020, October). Depression severity is associated with long-term opioid abstinence in youth with opioid use disorders receiving buprenorphine/naloxone treatment: 12-month outcomes [Poster presentation]. Presented at the 12th Annual National Networks of Depression Centers Conference, Virtual.

Impact of marijuana legislation on marijuana and cannabidiol related attitudes, perceptions, and behaviors among adolescents receiving mood disorder treatment in the United States

Published:

Citation: Hammond, C.J., Moon, Y.J., Fristad, M., Kady, A., Schneck, C.D., Sullivan, A.E., Batt, M.M., Ghaziuddin, N., Leffler, J.M., Singh, M.K., Weinstein, S. & Hulvershorn, L., & Miller, L. (2021, October). Impact of marijuana legislation on marijuana and cannabidiol related attitudes, perceptions, and behaviors among adolescents receiving mood disorder treatment in the United States [Poster presentation]. Presented at the 13th Annual National Networks of Depression Centers Conference, Virtual.

Childhood and Adolescent Stress Predict Problem-Drinking Change in Different Periods of the Adult Lifespan: Results in a U.S.-Representative Sample

Published:

Citation: Kady, A., Stephenson, A., Kwan, T., & Lee, M. (2022, March). Childhood and Adolescent Stress Predict Problem-Drinking Change in Different Periods of the Adult Lifespan: Results in a U.S.-Representative Sample [Poster presentation]. Presented at The Society for Research on Adolescence Biennial Meeting, New Orleans, L.A.

Reward and Relief Phenotypes in Pharmacotherapy Development

Published:

Citation: Ray, L., Kady, A., & Grodin, E. (Forthcoming). Reward and Relief Phenotypes in Pharmacotherapy Development. Upcoming oral presentation at the American Psychological Association Annual Conference. Washington, D.C.